how to use ZOMIG Nasal Spray

Just point and press for a single 5mg dose of ZOMIG

The usual dose is a single nasal spray taken into 1 nostril. If your headache comes back after your first dose, you may take a second dose anytime after 2 hours of taking the first dose. For any attack where the first dose did not work, do not take a second dose without talking with your doctor. Do not take more than a total of 10 mg of ZOMIG (tablets or spray combined) in any 24-hour period. If you take too much medicine, contact your doctor, hospital emergency department, or poison control center right away.

Parts of ZOMIG Nasal Spray

  • Protective Cap: Guards the tip. Do not remove the protective cap until just before you are ready to use.
  • Tip: Located under the protective cap. This is the part you put into your nostril. The medicine comes out of a tiny hole in the top.
  • Finger-grips: Hold here when using the sprayer.
  • Plunger: Press when you place the top into your nostril. This sprayer only works once.

Steps for using ZOMIG Nasal Spray

Please read all steps before using for the first time.

  • Blow your nose gently before use
  • Remove the protective cap
  • Hold the nasal sprayer device with your fingers and thumb
  • Insert the sprayer gently into 1 nostril while blocking the other
  • Tilt your head back slightly
  1. Remove cap.
  2. Hold device as show. Block one nostril and tilt head back slightly.
  3. Insert into opposite nostril and depress plunger.

Do not press the plunger yet

  • Breathe in gently through your nose and press the plunger firmly with your thumb at the same time
  • Keep your head slightly tilted back and remove the tip from your nose
  • Breathe gently through your mouth for 5 to 10 seconds

You may feel liquid in your nose or the back of your throat. This is normal and will soon pass.

Do not spray the contents of the device in your eyes.

Important Safety Information

ZOMIG is a prescription medication used for the treatment of migraine headaches in adults.
ZOMIG is not for the prevention of migraines.

  • Do not take ZOMIG if your headache is not a migraine
  • Do not take ZOMIG if your headache is hemiplegic or basilar migraine (If you are unsure about this, ask your doctor)
  • Do not take ZOMIG if you have heart disease, history of, or risk factors for heart disease, uncontrolled high blood pressure, circulation (blood flow) problems, or have had a stroke. Only your doctor can determine if ZOMIG is right for you
  • ZOMIG should not be used within 24 hours of another 5-HT1 agonist (triptans), ergotamine-containing or ergot-type medication (for headache), or within 2 weeks of an MAO-A inhibitor (for depression)
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding because ZOMIG may not be right for you
  • ZOMIG, like other triptans, may be associated with a potentially life-threatening condition called serotonin syndrome, mainly when taken together with certain antidepressants. Inform your doctor of all your medications prior to taking ZOMIG
  • Phenylketonurics: ZOMIG-ZMT® (zolmitriptan) Orally Disintegrating Tablets contain phenylalanine, a component of aspartame
  • Safety and effectiveness of ZOMIG in pediatric patients have not been established
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Nasal Spray include unusual taste, tingling sensation, skin sensitivity, and dizziness
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Tablets and ZOMIG-ZMT include dizziness; tightness, pressure, pain in the neck, throat, or jaw; fatigue; tingling; drowsiness; and nausea

Talk to your doctor about prescription ZOMIG.

Read the full Prescribing Information for ZOMIG Nasal Spray (PDF — 122KB)

Read the full Prescribing Information for ZOMIG Tablets and ZOMIG-ZMT (PDF — 194KB)

Read the Consumer Friendly Brief Summary (PDF — 480KB)

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.