ZOMIG—side effects

The most common side effects reported by patients in clinical trials for ZOMIG Tablets and ZOMIG-ZMT Orally Disintegrating Tablets were:

  • Dizziness
  • Tightness, pressure, or pain sensation (such as in the throat, neck, or chest)
  • Fatigue
  • Tingling
  • Drowsiness
  • Nausea

The most common side effects reported by patients in clinical trials for ZOMIG Nasal Spray were:

  • Unusual taste, dry mouth
  • Tingling sensation, skin sensitivity, especially around the nose
  • Pain, pressure, and tightness sensations (such as in the nose, throat, or chest)
  • Drowsiness, weakness, dizziness
  • Nausea

In very rare cases, patients taking triptans may experience serious side effects, such as heart attacks, increases in blood pressure, stroke, life-threatening disturbances of heart rhythm, constriction of blood vessels in the abdomen or other parts of the body, or serious allergic reactions. Extremely rarely, patients have died from these events.

Call your doctor right away if you have any of the following problems after taking ZOMIG

  • Tightness, pain, pressure or heaviness in your chest, throat, neck, or jaw that is severe or does not go away
  • Shortness of breath or wheezing
  • Bloody diarrhea, or sudden or severe stomach pain
  • Hives; tongue, mouth, lip or throat swelling
  • Problems seeing
  • Unusual weakness or numbness

Some people who take ZOMIG may have a reaction called serotonin syndrome, which can be life-threatening. In particular, this reaction may occur when they use ZOMIG together with certain types of antidepressants known as SSRIs or SNRIs. Symptoms may include confusion, hallucinations, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and/or diarrhea. Call your doctor immediately if you have any of these symptoms after taking ZOMIG.

Important Safety Information

ZOMIG is a prescription medication used for the treatment of migraine headaches in adults.
ZOMIG is not for the prevention of migraines.

  • Do not take ZOMIG if your headache is not a migraine
  • Do not take ZOMIG if your headache is hemiplegic or basilar migraine (If you are unsure about this, ask your doctor)
  • Do not take ZOMIG if you have heart disease, history of, or risk factors for heart disease, uncontrolled high blood pressure, circulation (blood flow) problems, or have had a stroke. Only your doctor can determine if ZOMIG is right for you
  • ZOMIG should not be used within 24 hours of another 5-HT1 agonist (triptans), ergotamine-containing or ergot-type medication (for headache), or within 2 weeks of an MAO-A inhibitor (for depression)
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding because ZOMIG may not be right for you
  • ZOMIG, like other triptans, may be associated with a potentially life-threatening condition called serotonin syndrome, mainly when taken together with certain antidepressants. Inform your doctor of all your medications prior to taking ZOMIG
  • Phenylketonurics: ZOMIG-ZMT® (zolmitriptan) Orally Disintegrating Tablets contain phenylalanine, a component of aspartame
  • Safety and effectiveness of ZOMIG in pediatric patients have not been established
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Nasal Spray include unusual taste, tingling sensation, skin sensitivity, and dizziness
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Tablets and ZOMIG-ZMT include dizziness; tightness, pressure, pain in the neck, throat, or jaw; fatigue; tingling; drowsiness; and nausea

Talk to your doctor about prescription ZOMIG.

Read the full Prescribing Information for ZOMIG Nasal Spray (PDF — 122KB)

Read the full Prescribing Information for ZOMIG Tablets and ZOMIG-ZMT (PDF — 194KB)

Read the Consumer Friendly Brief Summary (PDF — 480KB)

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.