3 forms of ZOMIG

Which form of ZOMIG is best for you?

Use this information to help discuss with your health care professional, what form of ZOMIG is best for you.

Learn more about each form:

Or use the Formulation Finder—an easy-to-use chart with facts about the 3 forms of ZOMIG.

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  • ZOMIG® Tablets
    Type of headache Moderate or severe migraine Moderate or severe migraine
    Dosage ZOMIG Tablets 2.5mg or placebo ZOMIG Tablets 5mg or placebo
    Time that moderate or severe headache was said to change to mild or painless 45 minutes
    For 24.5% taking ZOMIG Tablets 2.5mg
    For 12.4% taking placebo
    2 hours
    For 58.9% taking ZOMIG Tablets 2.5mg
    For 34.6% taking placebo     		45 minutes
    For 26.9% taking ZOMIG Tablets 5mg
    For 17.3% taking placebo
    2 hours
    For 62.1% taking ZOMIG Tablets 5mg
    For 36% taking placebo
    Number of patients in study 487 taking ZOMIG Tablets 2.5mg
    247 taking placebo    		 482 taking ZOMIG Tablets 5mg
    252 taking placebo

    ZOMIG Tablets: convenience in a conventional tablet

    • Provides fast, powerful migraine relief in tablet form
    • Available in 2.5mg and 5mg doses

    Headache response* as early as 45 minutes with ZOMIG Tablets 2.5mg and 5mg

    In the only direct comparison of 2.5 and 5mg, there was little added benefit from the larger dose, but side effects were generally increased at 5 mg.

    * Headache response is defined as a moderate or severe headache improving to mild or no pain.

  • ZOMIG-ZMT®
    Type of headache Moderate or severe migraine Moderate or severe migraine
    Dosage ZOMIG-ZMT 2.5mg or placebo ZOMIG-ZMT 5mg or placebo
    Time that moderate or severe headache was said to change to mild or painless 1 hour
    For 45% taking ZOMIG-ZMT 2.5mg
    For 19% taking placebo
    2 hours
    For 63% taking ZOMIG-ZMT 2.5mg
    For 22% taking placebo     		30 minutes
    For 16.5% taking ZOMIG-ZMT 5mg
    For 12.5% taking placebo
    2 hours
    For 59% taking ZOMIG-ZMT 5mg
    For 30.6% taking placebo
    Number of patients in study 231 taking ZOMIG-ZMT 2.5mg
    239 taking placebo    		 329 taking ZOMIG-ZMT 5mg
    341 taking placebo

    ZOMIG-ZMT Orally Disintegrating Tablets: you don't need water to take it

    • Fast, powerful relief in a form that quickly dissolves on your tongue
    • Good for situations when you can’t take your migraine medication because you don’t have water—at work or dropping the kids at school
    • A suitable option if you experience nausea caused by the migraine attack
    • Available in 2.5mg and 5mg doses

    Headache response* as early as 30 minutes with ZOMIG-ZMT 5mg

    * Headache response is defined as a moderate or severe headache improving to mild or no pain.

  • ZOMIG® Nasal Spray
    Type of headache Moderate or severe migraine
    Dosage ZOMIG Nasal Spray 5mg or placebo
    Time that moderate or severe headache was said to change to mild or painless 10 minutes
    For 15.1% taking ZOMIG Nasal Spray 5mg
    For 9.1% taking placebo
    2 hours
    For 64.8% taking ZOMIG Nasal Spray 5mg
    For 23.9% taking placebo
    Number of patients in study 461 taking ZOMIG Nasal Spray 5mg
    451 taking placebo

    For some patients, ZOMIG Nasal Spray provides headache response in as early as 10 minutes*

    • A great option for your busy life when you want to keep your medication handy
    • Available in a 5mg dose

    Headache response* as early as 30 minutes with ZOMIG Nasal Spray 5mg

    * Headache response is defined as a moderate or severe headache improving to mild or no pain.

    How to use ZOMIG Nasal Spray


Formulation Finder

Find the form of ZOMIG that's best for you

Print Formulation Finder PDF (PDF — 295KB)

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Find more information about each form of ZOMIG: ZOMIG Tablets, ZOMIG-ZOMIG Orally Disintegrating Tablets, or ZOMIG Nasal Spray.

Important Safety Information

ZOMIG is a prescription medication used for the treatment of migraine headaches in adults.
ZOMIG is not for the prevention of migraines.

  • Do not take ZOMIG if your headache is not a migraine
  • Do not take ZOMIG if your headache is hemiplegic or basilar migraine (If you are unsure about this, ask your doctor)
  • Do not take ZOMIG if you have heart disease, history of, or risk factors for heart disease, uncontrolled high blood pressure, circulation (blood flow) problems, or have had a stroke. Only your doctor can determine if ZOMIG is right for you
  • ZOMIG should not be used within 24 hours of another 5-HT1 agonist (triptans), ergotamine-containing or ergot-type medication (for headache), or within 2 weeks of an MAO-A inhibitor (for depression)
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding because ZOMIG may not be right for you
  • ZOMIG, like other triptans, may be associated with a potentially life-threatening condition called serotonin syndrome, mainly when taken together with certain antidepressants. Inform your doctor of all your medications prior to taking ZOMIG
  • Phenylketonurics: ZOMIG-ZMT® (zolmitriptan) Orally Disintegrating Tablets contain phenylalanine, a component of aspartame
  • Safety and effectiveness of ZOMIG in pediatric patients have not been established
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Nasal Spray include unusual taste, tingling sensation, skin sensitivity, and dizziness
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Tablets and ZOMIG-ZMT include dizziness; tightness, pressure, pain in the neck, throat, or jaw; fatigue; tingling; drowsiness; and nausea

Talk to your doctor about prescription ZOMIG.

Read the full Prescribing Information for ZOMIG Nasal Spray (PDF — 122KB)

Read the full Prescribing Information for ZOMIG Tablets and ZOMIG-ZMT (PDF — 194KB)

Read the Consumer Friendly Brief Summary (PDF — 480KB)

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.